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吉林大学建校75周年系列学术活动——基础医学院学术报告


报告题目:Systematic identification of silencer elements in the human genome

  人:宝旭   副教授 大学医学中心

报告时间:2021929日(周三)13:30

报告地点: 基础楼二楼会议室

报告人简介:

2013年博士毕业于荷癌症研究所,2013-2014年在荷癌症研究所从事博士后工作,2014年至2018年,在斯坦福大学医学院遗传系从事博士后工作。20182021年,在荷大学医学中心化学和胞生物学系担任助理教授2021年至今,在荷大学医学中心化学和胞生物学系担任教授。 博士工作期,基于蒽疗药物,发现并定了一种全新的物作用机制-物直接介导组蛋白从染色的脱离,从而影响胞的表观遗传学和DNA损伤的修复。相关研究果以第一作者或共同通作者表在《Nature CommunicationsCancer Research ,Nature Chemical Biology 》等志。博士后工作期两种高通量筛选统对基因编码调节区的功能行研究。 

报告摘要:

The majority of the human genome does not encode proteins. Many of these noncoding regions contain important regulatory sequences that control gene expression. To date, most studies have focused on activators such as enhancers, but regions that repress gene expression-silencers-have not been systematically studied. We have developed a system that identifies silencer regions in a genome-wide fashion on the basis of silencer-mediated transcriptional repression of caspase 9. We found that silencers are widely distributed and may function in a tissue-specific fashion. These silencers harbor unique epigenetic signatures and are associated with specific transcription factors. Silencers also act at multiple genes, and at the level of chromosomal domains and long-range interactions. Deletion of silencer regions linked to the drug transporter genes ABCC2 and ABCG2 caused chemo-resistance. Overall, our study demonstrates that tissue-specific silencing is widespread throughout the human genome and probably contributes substantially to the regulation of gene expression and human biology.

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